A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX-THE SELDOMYCINS

III. THE STRUCTURES OF SELDOMYCIN FACTORS 1 AND 2

Abstract

The structures of seldomycin factors 1 and 2 have been determined by consideration of chemical degradation and spectral properties. Factor 1, also known as XK-88-1, is shown to be 6-0-(2-amino-2-deoxy-α-D-xylopyranosyl) paromamine (1) and factor 2, also known as XK-88-2, is shown to be 4'-deoxy-neamine (2GS). Mass spectral evidence has been obtained that suggests the most probable structure for seldomycin factor 3, also known as XK-88-3, is 6'-amino-6'-deoxyseldomycin factor 1 (12).