The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
CHEMICAL MODIFICATION OF CORIOLIN B
YOSHIO NISHIMURA, YOSHIYUKI KOYAMA, SUMIO UMEZAWA, TOMIO TAKEUCHI, MASAAKI ISHIZUKA, HAMAO UMEZAWA
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JOURNAL FREE ACCESS

1977 Volume 30 Issue 1 Pages 59-65

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Abstract
Several derivatives of 5-ketocoriolin B (8, 11, 12) chemically modified at C-8 have been synthesized. These derivatives showed antitumor and antibacterial activity of the same degree as 5-ketocoriolin B (4) and diketocoriolin B (5) which were the most active members of the known coriolin group antibiotics. These derivatives were more stable than 4 and 5 in acidic or alkaline solution.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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