THE STROBILURINS -NEW ANTIFUNGAL ANTIBIOTICS FROM THE BASIDIOMYCETE STROBILURUS TENACELLUS (PERS. ex FR.) SING

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The strobilurins are two antifungal antibiotics which were isolated from the mycelium of Strobilurus tenacellus strain No. 21602. The strobilurins A and B are highly active against yeasts and filamentous fungi. In vitro antitumor activity was tested using cells of the ascitic
form of EHRLICH carcinoma. The strobilurins strongly inhibited the incorporation of radioactive leucine, uridine, and thymidine into the acid-insoluble fraction of cells (protein, RNA, and DNA). The molecular formulas as determined by high resolution mass spectrometry are C₁₆H₁₈O₃ for strobilurin A and C₁₇H₁₉ClO₄ for strobilurin B.