MUTALOMYCIN, A NEW POLYETHER ANTIBIOTIC TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

Abstract

Mutalomycin is a new metal-complexing polyether antibiotic produced by a strain of Streptomyces mutabilis NRRL 8088. The metabolite, a monocarboxylic acid, was isolated as the sodium salt C₄₁H₆₉NaO₁₂. The structure of this polyether was established by X-ray analysis of its potassium salt C₄₁H₆₉KO₁₂. Mutalomycin contains six heterocyclic rings and is structurally related to nigericin. The metabolite is active against gram-positive bacteria and Eimeria tenella (chicken coccidiosis).