NOCARDICIN A, A NEW MONOCYCLIC β-LACTAM ANTIBIOTIC. IV

FACTORS INFLUENCING THE IN VITRO ACTIVITY OF NOCARDICIN A

Abstract

Factors influencing the in vitro antimicrobial activity of nocardicin A against Pseudomonas aeruginosa and Proteus mirabilis were investigated. Sodium chloride was identified as a major inhibitor. Some of the amino acids, sugars and divalent cations were found to be
minor inhibitors. The presence of potassium phosphates enhanced nocardicin A activity against P. aeruginosa, but antagonized the activity against P. mirabilis.