SYNTHESIS OF A ¹²⁵I-LABELLED DERIVATIVE OF THE ANTIBIOTIC GRISEOFULVIN

Abstract

A derivative of griseofulvin has been synthesised, in which the 2'-O-methyl group is replaced by a 2'-(2-iodoethoxy), ¹²⁵I-labelled group. This derivative is at least as potent as griseofulvin itself, when assayed for inhibition of growth on the Myxomycete Physarum polycephalum.