A NEW ANTITUMOR ANTIBIOTIC, SPORAMYCIN

Abstract

A new antitumor antibiotic, sporamycin, was isolated from the culture broth of Streptosporangium pseudovulgare strain No. PO-357.^* Sporamycin was prepared as a white powder by ammonium sulfate precipitation and chromatographic techniques using DEAE-cellulose and Sephadex G-50. The producing organism was similar to Streptosporangium pseudovulgare in a number of properties but differed in the biological activity of the culture broth and the color of the aerial mycelium on agar. Sporamycin is active against most Gram-positive bacteria and Sarcoma-180 solid tumors. It is heat labile, but stable at low temperature.