The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SEMISYNTHETIC β-LACTAM ANTIBIOTICS. II
PENICILLINS FROM α-HYDRAZINOARYLACETIC ACIDS
G. LIBASSI, R. MONGUZZI, R. BROGGI, G. BROCCALI, C. CARPI, G. PIFFERI
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JOURNAL FREE ACCESS

1977 Volume 30 Issue 5 Pages 376-381

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Abstract

A number of penicillins (2) have been synthesized from the α-hydrazinoarylacetic acids (4) via the activated chloride hydrochlorides (5) or via the mixed anhydride of the corresponding N2-benzyloxycarbonyl derivatives (6). The penicillins, 2b, e, j, show good activity against gram-positive and gram-negative bacteria and enhanced penicillinase resistance in comparison with ampicillin.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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