KUWAITIMYCIN, EFFECT ON SYNTHESIS OF LIPIDS IN BACILLUS SUBTILIS CELLS

Abstract

The effects exerted by kuwaitimycin on synthesis of lipids as well as some metabolic activities of Bacillus subtilis were studied. The antibiotic not only arrested the incorporation of ¹⁴C-acetate into the microbial lipids but also altered the fatty acids pattern, contents of i-C 15, a-C 15, i-C 17 and a-C 17 were markedly reduced, concomitant with an increase in the contents of i-C 14 and n-C 14. Moreover, the rates of synthesis of phospholipids were decreased by the drug, especially that of phosphatidyl ethanolamine.