IN VITRO ANTIMICROBIAL ACTIVITY COMPARISON OF CEFACLOR (COMPOUND 99638), CEPHRADINE, AND CEPHALOTHIN

Abstract

Cefaclor [3-chloro-7-D-(2-phenylglycemamido)-3-cephem-4-carboxylic acid], has been reported by PRESTON and WICK as a new orally absorbed semi-synthetic cephalosporin (14th ICAAC Meeting, paper #426, 1974). This drug is structurally similar to the clinically available oral cephalosporins, cephradine and cephalexin.⁴⁾ The significant structural difference is the substitution of a chloro group for the methyl group found in cephalexin and cephradine (Fig. 1). This study compares the in vitro antimicrobial activity of cefaclor with that of cephradine and cephalothin against seven commonly encountered bacterial species.