The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
GLOBOMYCIN, A NEW PEPTIDE ANTIBIOTIC WITH SPHEROPLAST-FORMING ACTIVITY
III. STRUCTURAL DETERMINATION OF GLOBOMYCIN
MUTSUO NAKAJIMAMASATOSHI INUKAITATSUO HANEISHIAKIRA TERAHARAMAMORU ARAITAKESHI KINOSHITACHIHIRO TAMURA
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Volume 31 (1978) Issue 5 Pages 426-432

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Abstract

The structure of globomycin has been determined by mass, PMR and CMR spectra and by chemical degradation. Globomycin is a new cyclic peptide antibiotic composed of L-serine, L-allo-threonine, glycine, N-methylleucine, L-allo-isoleucine and 3-hydroxy-2-methyl-nonaic acid. Among these components, L-allo-threonine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid are novel components from natural products. A newly developed mass analysis has been introduced for determining the diastereoisomers of allo-threonine.

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© Japan Antibiotics Research Association
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