The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
INCREASED PRODUCTION OF THE ANTIBIOTIC AURODOX (X-5108) BY AURODOX-RESISTANT MUTANTS
JOEL UNOWSKYDONALD C. HOPPE
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1978 Volume 31 Issue 7 Pages 662-666

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Abstract

Conventional strain and media improvement techniques were of limited success in increasing yields of the antibiotic aurodox (X-5108) above 0.5 g/liter. Higher yields were obtained by reversion of a zero producer followed by the selection of mutants resistant to aurodox. Resistant strains of Streptomyces goldiniensis ATCC 21386 able to grow on 2 g/liter of Aurodox produced greater than 2.5 g/liter of antibiotic. The rate of yield increase leveled off as the strains became resistant to greater than 2 g/liter of aurodox. These strains, in contrast to those sensitive to aurodox, gave a positive response to conventional mutagenic methods for further yield increases.

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© Japan Antibiotics Research Association
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