The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
BIOSYNTHETIC RELATIONSHIPS AMONG THE SECALONIC ACIDS
ISOLATION OF EMODIN, ENDOCROCIN AND SECALONIC ACIDS FROM PYRENOCHAETA TERRESTRIS AND ASPERGILLUS ACULEATUS
ITSUO KUROBANELEO C. VININGA. GAVIN MCINNES
Author information
JOURNALS FREE ACCESS

1979 Volume 32 Issue 12 Pages 1256-1266

Details
Abstract

Cynodontin, emodin, endocrocin and secalonic acids A, E and G have been isolated from five strains of Pyrenochaeta terrestris. Aspergillus aculeatus produces emodin, endocrocin and secalonic acids B, D and F. No cynodontin was detected. Isolation of emodin in small amounts supports previous evidence that it is an intermediate in secalonic acid biosynthesis. Isolation of cynodontin and endocrocin, which are co-produced with secalonic acids in other organisms, suggests that these compounds are formed by a common branching pathway. A natural isolate of P. terrestris contained variant strains which produced different relative amounts of secalonic acids A, E and G. From the combinations of secalonic acids produced in organisms so far examined it is concluded that precursor tetrahydroxanthone units are formed in pairs differing in stereo-chemistry only at C-5 or at the trans-invariant C-6 : C-10a positions. A possible biosynthetic pathway is discussed.

Information related to the author
© Japan Antibiotics Research Association
Previous article Next article
feedback
Top