THE STRUCTURES OF FORTIMICINS C, D, AND KE

Abstract

Fortimicins C, D, and KE are new aminocyclitol antibiotics produced by a mutant of fortimicin-producing organisms. Their structures have been determined by ¹H and ¹³C NMR and mass spectra and chemical degradations. Fortimicin C is 4-N-hydantoylfortimicin B, fortimicin KE is 6'-demethylfortimicin B, and fortimicin D is 4-N-glycylfortimicin KE. The last two antibiotics have purpurosamine C instead of 6-epi-purpurosamine B.