ISOLATION AND STRUCTURE ELUCIDATION OF A NOVEL GRISEORHODIN

Abstract

Three antibiotics possessing cytotoxic properties were isolated from a strain of Streptomyces griseus (FCRC-57). One was found to be identical with griseorhodin A.^2-6) A second, FCRC-57-U, was found to be identical to griseorhodin C⁷⁾. FCRC-57-G is a new antibiotic structurally related to griseorhodins A and C, and is active against KB cells in vitro. The structure of this new antibiotic was determined using mass spectrom/etry, proton and carbon nuclear magnetic resonance spectroscopy and synthesis.