The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
THE SYNTHESIS OF ε-RHODOMYCINONE- AND CARMINOMYCIN- 11-METHYL ETHERS
JOHN M. ESSERYTERRENCE W. DOYLE
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1979 Volume 32 Issue 3 Pages 247-249

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Abstract

The conversion of ε-rhodomycinone to its 11-methyl ether via selective hydrolysis of the 4, 6, 7, 11-tetraacetate is described. This series of reactions was used as a model for the conversion of carminomycin to its 11-methyl ether. The anti-tumor activity of the latter compound was less than that of both carminomycin and its 4-methyl ether (daunomycin).

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© Japan Antibiotics Research Association
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