The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
IZUMENOLIDE-A NOVEL β-LACTAMASE INHIBITOR PRODUCED BY MICROMONOSPORA
I. DETECTION, ISOLATION AND CHARACTERIZATION
WEN-CHIN LIUGAIL ASTLEERRY SCOTT WELLS Jr.WILLIAM H. TREJOPACIFICO A. PRINCIPEMARLENE L. RATHNUMWILLIAM L. PARKEROCTAVIAN R. KOCYRICHARD B. SYKES
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1980 Volume 33 Issue 11 Pages 1256-1261

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Abstract

Micromonospora chalcea subsp. izumensis produces a novel β-lactamase inhibitor izumenolide (EM4615). Isolation of izumenolide was performed by extraction into butanol under acidic conditions and then back extraction into water at neutrality. The compound was precipitated from the aqueous phase by the addition of calcium or barium salts. Further purification was achieved by distribution in BuOH-1N NaOH. Izumenolide is a macrolide containing sulfate ester groups.

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© Japan Antibiotics Research Association
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