Abstract
The antibacterial activity of acyl derivatives of tylosin were examined in vitro and in vitro. The 4''-acyl group in the acylated tylosins enhanced the antibacterial activity and antimycoplasmal activity against some macrolide-resistant strains. The orally administered 3-acetyl-4''-isovaleryltylosin produced a higher blood level in mice and rabbits than tylosin and a good therapeutic effect on the infection of Staphylococcus aureus Smith in mice.
© Japan Antibiotics Research Association
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