The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SYNTHESIS AND BIOLOGICAL ACTIVITY OF A NEW SEMISYNTHETIC CEPHALOSPORIN, CN-92, 982
T. F. MICH, G. G. HUANG, P. W. K. WOO, J. P. SANCHEZ, C. L. HEIFETZ, D. SCHWEISS, U. KROLLS, M. P. HUTT, T. P. CULBERTSON, T. H. HASKELL
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1980 Volume 33 Issue 11 Pages 1352-1356

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Abstract

A new broad spectrum semisynthetic cephalosporin (CN-92, 982) was prepared from the condensation of an acetylaminoacylaminophenyl pyridone with trans-7-[(D-2-phenylglycyl) amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-Δ3-cephem-4-carboxylic acid. The new cephalosporin displayed an in vitro antibacterial spectrum similar to other cephaloglycine types such as cefoperazone and SM-1652. The compound produced a high and prolonged blood level following a single intramuscular dose in a dog.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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