Bu-2313, A NEW ANTIBIOTIC COMPLEX ACTIVE AGAINST ANAEROBES

I. PRODUCTION, ISOLATION AND PROPERTIES OF Bu-2313 A AND B

Abstract

An unidentified oligosporic actinomycete strain, No. E864-61, produced two new antibiotics, Bu-2313 A (C₂₇H₃₅NO₉) and Bu-2313 B (C₂₆H₃₃NO₉). Bu-2313 A and B each exhibited a broad antibiotic spectrum against Gram-positive and Gram-negative anaerobic bacteria, and showed in vivo activity against experimental infections produced by B. fragilis and C. perfringens. Bu-2313 also inhibited some aerobic bacteria such as streptococci. Bu-2313 B was approximately two-fold more active than Bu-2313 A.