TRIOXACARCINS, NOVEL ANTITUMOR ANTIBIOTICS II. ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND MODE OF ACTION

TATSUYA TAMAOKI; KUNIKATSU SHIRAHATA; TAKAO IIDA; FUSAO TOMITA

doi:10.7164/antibiotics.34.1525

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

TRIOXACARCINS, NOVEL ANTITUMOR ANTIBIOTICS

II. ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND MODE OF ACTION

TATSUYA TAMAOKI, KUNIKATSU SHIRAHATA, TAKAO IIDA, FUSAO TOMITA

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JOURNAL FREE ACCESS

1981 Volume 34 Issue 12 Pages 1525-1530

DOI https://doi.org/10.7164/antibiotics.34.1525

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Abstract

Novel antitumor antibiotics, trioxacarcin complex, were isolated from the fermentation broth of Streptomyces bottropensis DO-45 by the use of non-ionic porous resin and silica gel chromatography. The purified components (trioxacarcins A, B and C) were characterized as new antibiotics by their physico-chemical properties and chromatographic behaviors. The mode of action of trioxacarcin A against Bacillus subtilis was found to be through the of DNA synthesis.

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