SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 7β-[2-(2-AMINOTHIAZOL-4-YL)ACETAMIDO]CEPHALOSPORIN DERIVATIVES

VI. ALTERNATIVE SYNTHESES OF 7β-[2-(2-AMINOTHIAZOL-4-YL)-(Z)-2-METHOXYIMI NO-ACETAMIDO] CEPHALOSPORIN DERIVATIVES

Abstract

Alternative syntheses of 7β-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-cephalosporins ( 1) were investigated. Of these, a sequence of reactions starting from 6a via 8a, 9a, 13a and 13b afforded a convenient route to 1a which is especially useful for the preparation of labeled cefmenoxime. Structures of nitrone compounds which were formed as by-products are discussed.