C-19393 S2 AND H2, NEW CARBAPENEM ANTIBIOTICS
IV. INHIBITORY ACTIVITY AGAINST β-LACTAMASES
1981 Volume 34 Issue 2 Pages 212-217
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1981 Volume 34 Issue 2 Pages 212-217
New carbapenem antibiotics, C-19393 S2 and H2, have been found to be potent and broad-spectrum inhibitors of β-lactamases. Among 11 types of β-lactamases tested, those from Escherichia coli (plasmid-bearing), Klebsiella pneumoniae, Proteus vulgaris, Serratia marcescens and Bacteroides fragilis were especially sensitive. They also inhibited cephalosporinases insensitive to clavulanic acid. The inhibition by C-19393 S2 and H2 was of progressive type, except for the inhibition of E. coli enzyme (plasmid-mediated type I) by C-19393 H2. The inhibition of E. coli β-lactamase by C-19393 S2 was irreversible, while that by C-19393 H2 was reversible.
