The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
STUDIES ON NEPLANOCIN A, NEW ANTITUMOR ANTIBIOTIC. I
PRODUCING ORGANISM, ISOLATION AND CHARACTERIZATION
SATOSHI YAGINUMANAOKI MUTOMASATOSHI TSUJINOYASUHIRO SUDATEMITSUO HAYASHIMASARU OTANI
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1981 Volume 34 Issue 4 Pages 359-366

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Abstract

Neplanocin A, C11H13N5O3, is a novel carbocyclic analog of adenosine with cyclopentene. It was isolated from the culture filtrate of Ampullariella regularis A11079 by means of ion-exchange, carbon, silica gel adsorption, or partition chromatography. Neplanocin A forms crystals, and is stable at acidic or alkaline pH. Neplanocin A has cytotoxicity against L5178Y cells in culture and showed a remarkable effect on the life prolongation of mice infected with L1210 leukemia.

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© Japan Antibiotics Research Association
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