The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
DIHYDROMEVINOLIN, A POTENT HYPOCHOLESTEROLEMIC METABOLITE PRODUCED BY ASPERGILLUS TERREUS
G. ALBERS-SCHÖNBERGH. JOSHUAM. B. LOPEZO. D. HENSENSJ. P. SPRINGERJ. CHENS. OSTROVEC. H. HOFFMANA. W. ALBERTSA. A. PATCHETT
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1981 Volume 34 Issue 5 Pages 507-512

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Abstract

A new, potent hypocholesterolemic agent is produced by cultures of Aspergillus terreus. The isolation of the compound and its characterization as 4a, 5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for dihydromevinolin and mevinolin in three biological assays are given: in vitro inhibition of HMG-CoA reductase, inhibition of sterol synthesis in cell cultures, and inhibition of cholesterol synthesis in vivo in rats.

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