The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
KIJANIMICIN (Sch 25663), A NOVEL ANTIBIOTIC PRODUCED BY ACTINOMAD URA KIJANIATA SCC 1256
FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES
J. ALLAN WAITZANN C. HORANMANOHAR KALYANPURBONG K. LEEDAVID LOEBENBERGJOSEPH A. MARQUEZGEORGE MILLERMAHESH G. PATEL
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1981 Volume 34 Issue 9 Pages 1101-1106

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Abstract

A novel antibiotic complex has been isolated from the fermentation broth of a new species of Actinomadura, A. kijaniata SCC 1256. The complex was separated from the broth by a solvent extraction procedure and consists of 1 major component, designated kijanimicin, and 3 minor components. Kijanimicin was isolated from the complex by column chromatography and/or preparative high pressure liquid chromatography. Structurally the compound is a unique, large acid enol antibiotic and possesses an unusual in vitro spectrum of activity against some Gram-positive and anaerobic microorganisms. In vivo it has also shown interesting activity against malaria.

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© Japan Antibiotics Research Association
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