The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
PREPARATION AND BIOLOGICAL ACTIVITIES OF 10-DECARBAMOYLOXY-9-DEHYDROMITOMYCIN B AND ITS ANALOGS
CHIKAHIRO URAKAWAHARUKO TSUCHIYAKIN-ICHI NAKANONOBUO NAKAMURA
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1981 Volume 34 Issue 9 Pages 1152-1156

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Abstract

A new naturally occurring mitomycin, 10-decarbamoyloxy-9-dehydromitomycin B (1), was prepared by treating mitomycin B with sodium hydride. Its analogs having an exo-cyclic double bond in their structure were also synthesized. These compounds showed antibacterial and cytotoxic activities. Among them, 7-amino-l0-decarbamoyloxy-9-dehydro-7-demethoxymitomycin B (2) was the most potent growth inhibitor of KB cells in vitro and, accordingly, it appears to be a potential antitumor agent.

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© Japan Antibiotics Research Association
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