The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
SAFRACINS, NEW ANTITUMOR ANTIBIOTICS
III. BIOLOGICAL ACTIVITY
YOSHIFUMI IKEDA, YOSHIKO SHIMADA, KATSUHIKO HONJO, TAKEKI OKUMOTO, TOMOHIKO MUNAKATA
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1983 Volume 36 Issue 10 Pages 1290-1294

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Abstract

Safracins A and B have antibacterial activity against Gram-positive and Gram-negative bacteria in vitro but no therapeutic activity in mice infected with Staphylococcus aureus. Safracins A and B induce abnormal morphological changes in Echerichia coli cells. Tests with transplantable mice tumors demonstrate that safracins A and B inhibit the growth of P388 leukemia and IMC carcinoma.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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