DISCOVERY, ISOLATION AND STRUCTURE OF NOVEL CEPHAMYCINS OF STREPTOMYCES CHARTREUSIS

SHIGEHARU INOUYE; MICHIO KOJIMA; TAKASHI SHOMURA; KATSUYOSHI IWAMATSU; TOMIZO NIWA; YASUMITSU KONDO; TARO NIIDA; YASUAKI OGAWA; KEN KUSAMA

doi:10.7164/antibiotics.36.115

DISCOVERY, ISOLATION AND STRUCTURE OF NOVEL CEPHAMYCINS OF STREPTOMYCES CHARTREUSIS

SHIGEHARU INOUYE, MICHIO KOJIMA, TAKASHI SHOMURA, KATSUYOSHI IWAMATSU, TOMIZO NIWA, YASUMITSU KONDO, TARO NIIDA, YASUAKI OGAWA, KEN KUSAMA

Author information

SHIGEHARU INOUYE
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
MICHIO KOJIMA
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
TAKASHI SHOMURA
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
KATSUYOSHI IWAMATSU
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
TOMIZO NIWA
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
YASUMITSU KONDO
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
TARO NIIDA
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
YASUAKI OGAWA
Pharmaceutical and Developmental Laboratories, Meiji Seika Kaisha Ltd.
KEN KUSAMA
Pharmaceutical and Developmental Laboratories, Meiji Seika Kaisha Ltd.

JOURNAL FREE ACCESS

1983 Volume 36 Issue 2 Pages 115-124

DOI https://doi.org/10.7164/antibiotics.36.115

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Abstract

By the use of HPLC technique after treatment with β-lactamases, two novel cephamycins, SF-1623 and SF-1623B, were discovered and isolated from the fermentation broth of Streptomyces chartreusis SF-1623. The structures of SF-1623 and SF-1623B were determined to contain 3-sulfothiomethyl and 3-hydroxymethyl groups respectively, by chemical and enzymatic transformation reactions. Studies on the fermentation condition and process for the large scale preparation of antibiotic SF-1623 are also described.

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