NEW ANTIBIOTIC, ISOHEMATINIC ACID II. PHYSICO-CHEMICAL PROPERTIES, STRUCTURAL ELUCIDATION AND BIOLOGICAL ACTIVITIES

YASUHIRO ITOH; MICHIKO TAKEUCHI; KEIKO SHIMIZU; SHUJI TAKAHASHI; AKIRA TERAHARA; TATSUO HANEISHI

doi:10.7164/antibiotics.36.497

NEW ANTIBIOTIC, ISOHEMATINIC ACID

II. PHYSICO-CHEMICAL PROPERTIES, STRUCTURAL ELUCIDATION AND BIOLOGICAL ACTIVITIES

YASUHIRO ITOH, MICHIKO TAKEUCHI, KEIKO SHIMIZU, SHUJI TAKAHASHI, AKIRA TERAHARA, TATSUO HANEISHI

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JOURNAL FREE ACCESS

1983 Volume 36 Issue 5 Pages 497-501

DOI https://doi.org/10.7164/antibiotics.36.497

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Abstract

Physico-chemical characterization of isohematinic acid revealed that this antibiotic has a succinimide nucleus. From elemental analysis, the molecular formula of isohematinic acid was determined to be C₈H₉NO₄. Isohematinic acid showed weak antimicrobial activities against anaerobic bacteria, such as Bacteroides fragilis and Propionibacterium acnes.

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