The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
LEPTOMYCINS A AND B, NEW ANTIFUNGAL ANTIBIOTICS
I. TAXONOMY OF THE PRODUCING STRAIN AND THEIR FERMENTATION, PURIFICATION AND CHARACTERIZATION
TETSUO HAMAMOTOSHIGEMICHI GUNJIHIROAKI TSUJITERUHIKO BEPPU
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1983 Volume 36 Issue 6 Pages 639-645

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Abstract

A strain of Streptomyces was found to produce new antifungal antibiotics. The active compounds were purified and separated into two substances named leptomycin A and B by high performance liquid chromatography. The molecular formulae of leptomycins A and B are C32H46O6 and C33H48O6 respectively, and physicochemical and biological properties of them are very similar to each other. Leptomycins A and B exhibit strong inhibitory activity against Schizosaccharomyces and Mucor.

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© Japan Antibiotics Research Association
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