The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
VANOXONIN, A NEW INHIBITOR OF THYMIDYLATE SYNTHETASE
FUMIAKI KANAITSUTOMU SAWAMASA HAMADAHIROSHI NAGANAWATOMIO TAKEUCHIHAMAO UMEZAWA
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1983 Volume 36 Issue 6 Pages 656-660

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Abstract

Vanoxonin, a new inhibitor of thymidylate synthetase, was found in cultured broths of the strain MG245-CF2 classified as Saccharopolyspora hirsuta. Vanoxonin, C15H25N3O9, was obtained as colorless powder. Vanoxonin forms a vanadium complex which exhibits a strong inhibition against thymidylate synthetase. The concentration for 50%. inhibition of the enzyme (IC50) was 0.7 μg/ml.

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© Japan Antibiotics Research Association
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