The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
STRUCTURE AND SYNTHESES OF TEXAZONE, 2-(N-METHYLAMINO)-3H-PHENOXAZIN-3-ONE-8-CARBOXYLIC ACID, AN ACTINOMYCETE METABOLITE
NANCY N. GERBERHARRY L. YALEW. A. TABERI. KUROBANEL. C. VINING
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1983 Volume 36 Issue 6 Pages 688-694

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Abstract

Cultures of actinomycete strain WRAT-210 produced a dark red crystalline metabolite which was named texazone. Spectroscopic evidence suggested that the structure of texazone is 2-(N-methylamino)-3 H-phenoxazin-3-one-8-carboxylic acid. The structure was confirmed by chemical synthesis through oxidative dimerization of ethyl 3-amino-4-hydroxybenzoate with 2-(N-methylamino)phenol and subsequent hydrolysis of the resultant phenoxazinone ester.

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