The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
DIFFERENTIAL CYTOTOXICITY TO HUMAN LUNG NORMAL DIPLOID, VIRUS-TRANSFORMED AND CARCINOMA CELLS
BY THE ANTITUMOR ANTIBIOTICS, AUROMOMYCIN AND MACROMOMYCIN, AND THEIR NON-PROTEIN CHROMOPHORES
NOBUHIKO MIWASATOSHI MIZUNOSUEHIKO OKAMOTO
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1983 Volume 36 Issue 6 Pages 715-720

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Abstract

With the use of three human lung cultured cell lines : normal diploid fibroblasts (WI38), their SV40-transformants (VA13) and carcinoma cells (A549), whose doubling times were similar, the cytotoxicity of the protein antitumor antibiotics, auromomycin (AUR) and macromomycin (MCR), was studied by colony formation method. The susceptibilities of the three cell lines to these antibiotics were in the order: WI38

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