DIFFERENTIAL CYTOTOXICITY TO HUMAN LUNG NORMAL DIPLOID, VIRUS-TRANSFORMED AND CARCINOMA CELLS

BY THE ANTITUMOR ANTIBIOTICS, AUROMOMYCIN AND MACROMOMYCIN, AND THEIR NON-PROTEIN CHROMOPHORES

Abstract

With the use of three human lung cultured cell lines : normal diploid fibroblasts (WI38), their SV40-transformants (VA13) and carcinoma cells (A549), whose doubling times were similar, the cytotoxicity of the protein antitumor antibiotics, auromomycin (AUR) and macromomycin (MCR), was studied by colony formation method. The susceptibilities of the three cell lines to these antibiotics were in the order: WI38