TOTAL SYNTHESIS OF EDEINE D

Abstract

Syntheses of the peptides with sequences postulated for active and inactive isomer of edeine D were carried out. The peptides obtained were identical with natural product in regard to chromatographic and electrophoretic properties. Biological data for synthesized compounds confirmed that in active and inactive isomer isoserine is linked with the α- or β-amino group of α, β-diaminopropionic acid, respectively.