1983 Volume 36 Issue 8 Pages 1020-1033
Cephalosporins with a 7β-[2-(5-amino-1, 2, 4-thiadiazol-3-yl)-2-oxyiminoacetamidol side chain were synthesized and their in vitro inhibitory potency was established. The compounds exhibit a strong antibacterial activity against various Gram-positive and Gram-negative bacteria. The antimicrobial activity is related to the oxime-substituent R1 and the C-3 substituent R2. Selected amino- 1, 2, 4-thiadiazolyl-cephems 1 show a prolonged half-Life in mice.