The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
CEPHALOSPORIN ANTIBIOTICS. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 7β-[2-(5-AMINO-1, 2, 4-THIADIAZOL-3-YL)-2-OXYIMINOACETAMIDO]CEPHALOSPORIN DERIVATIVES
I. CSENDESB. W. MÜLLERW. TOSCH
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1983 Volume 36 Issue 8 Pages 1020-1033

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Abstract

Cephalosporins with a 7β-[2-(5-amino-1, 2, 4-thiadiazol-3-yl)-2-oxyiminoacetamidol side chain were synthesized and their in vitro inhibitory potency was established. The compounds exhibit a strong antibacterial activity against various Gram-positive and Gram-negative bacteria. The antimicrobial activity is related to the oxime-substituent R1 and the C-3 substituent R2. Selected amino- 1, 2, 4-thiadiazolyl-cephems 1 show a prolonged half-Life in mice.

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© Japan Antibiotics Research Association
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