NEW α-AMYLASE INHIBITOR, TRESTATINS

I. ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF TRESTATINS A, B AND C

Abstract

Trestatin complex which exhibited a potent inhibitory activity on various α-amylases has been isolated from the culture filtrate of Streptomyces dimorphogenes nov. sp. NR-320-OM7HB. Three major components, trestatins A, B and C, have been purified by adsorption and ion-exchange chromatography. Their spectral and chemical properties suggested that trestatins were novel basic oligosaccharide homologues each characterized by the possession of a trehalose moiety at the non-reducing end of the molecule.