The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
IN VITRO BIOLOGICAL ACTIVITIES OF 6-ISOSTERIC PENICILLINS AND 7-ISOSTERIC CEPHALOSPORINS
JOHN C. SHEEHANELSIE CHACKOTHOMAS J. COMMONSYOUNG S. LODAGMAR R. PONZIALAN SCHWABACHERNADINE SOLOMONARNOLD L. DEMAIN
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1984 Volume 37 Issue 11 Pages 1441-1448

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Abstract

Antibiotic and penicillinase inhibitor activities of various penicillin and cephalosporin analogs are reported. The compounds include C-6 penicillin and C-7 cephalosporin carbon, oxygen and sulfur analogs obtained by replacing the NH of the amide side chains with CH2, O and S, respectively. In almost all cases, analogs were considerably less active than the standard compounds (benzylpenicillin and cephalothin), However, some of the analogs act as penicillinae inhibitors.

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© Japan Antibiotics Research Association
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