The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
ANTIMICROBIAL ACTION OF ε-POLY-L-LYSINE
SHOJI SHIMAHIROYOSHI MATSUOKATOSHIRO IWAMOTOHEIICHI SAKAI
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1984 Volume 37 Issue 11 Pages 1449-1455

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Abstract

The antimicrobial spectrum of ε-poly-L-lysine (n=25-30, ε-PL) was investigated by comparison with α-poly-L-lysine (n=50, α-PL). ε-PL showed antimicrobial activity against Gram-positive and-negative bacteria at concentrations of 1-8μg/ml. α-PL was less active than ε-PL A chain length of at least 10 L-lysine monomers was found to be optimum for antimicrobial activity. Chemical modification of the amino groups of ε-PL lowered its antibacterial activity. Studies on the mode of action of ε-PL suggest that adsorption of ε-PL to the bacterial cell surface plays an important role in its antibacterial activity.

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© Japan Antibiotics Research Association
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