The Journal of Antibiotics
CEPHABACINS, NEW CEPHEM ANTIBIOTICS OF BACTERIAL ORIGIN
II. ISOLATION AND CHARACTERIZATION
SETSUO HARADASHIGETOSHI TSUBOTANIHIDEO ONOHISAYOSHI OKAZAKI
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Volume 37 (1984) Issue 12 Pages 1536-1545

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Abstract

Fifteen components of new antibiotics, cephabacins, were isolated from the culture filtrates of Lysobacter lactamgenus YK-90, Xanthomonas lactanigenaYK-280 and X. lactaingena YK-278. They were purified by column chromatography using cation-exchange resins, activated carbon, high porous resins and cation-exchange Sephadex and by preparative reverse-phase HPLC. The basic, water-soluble antibiotics were characterized as having a cephem skeleton and oligopeptide(s) as a side chain constituent from their spectroscopic analyses and amino acid analyses.

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