The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
A-16686, A NEW ANTIBIOTIC FROM ACTINOPLANES
I. FERMENTATION, ISOLATION AND PRELIMINARY PHYSICO-CHEMICAL CHARACTERISTICS
BRUNO CAVALLERIHERMES PAGANIGIANCARLO VOLPEENRICO SELVAFRANCO PARENTI
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1984 Volume 37 Issue 4 Pages 309-317

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Abstract

Actinoplanes sp. ATCC 33076 is a new strain that was found to produce an antibiotic, designated A-16686, which is a complex of three closely-related polypeptides containing chlorinated phenyl moieties and D-mannose. Both the complex and the single fractions possess a good activity against Gram-positive bacteria. A-16686 specifically inhibits the synthesis of the bacterial cell wall.

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