SAKYOMICINS A, B, C AND D: NEW QUINONE-TYPE ANTIBIOTICS PRODUCED BY A STRAIN OF NOCARDIA TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL PROPERTIES

TORU NAGASAWA; HIDEHARU FUKAO; HIROSHI IRIE; HIDEAKI YAMADA

doi:10.7164/antibiotics.37.693

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

SAKYOMICINS A, B, C AND D: NEW QUINONE-TYPE ANTIBIOTICS PRODUCED BY A STRAIN OF NOCARDIA

TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL PROPERTIES

TORU NAGASAWA, HIDEHARU FUKAO, HIROSHI IRIE, HIDEAKI YAMADA

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JOURNAL FREE ACCESS

1984 Volume 37 Issue 7 Pages 693-699

DOI https://doi.org/10.7164/antibiotics.37.693

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Abstract

Actinomycete strain M-53, a new soil isolate, was found to produce four quinone-type antibiotics. Antibiotic sakyomicin components A, B, C and D were isolated from the fermentation broth of strain M-53 by XAD-2 column chromatography, silica gel column chromatography and Sephadex LH-20 column chromatography. The components are active against Gram-positive bacteria. Strain M-53 was identified as a strain of genus Nocardia.

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