PENITRICIN, A NEW CLASS OF ANTIBIOTIC PRODUCED BY PENICILLIUM ACULEATUM III. STRUCTURAL CONFIRMATION BY CHEMICAL SYNTHESIS AND BIOLOGICAL ACTIVITY

TORU OKUDA; NOBUO SHIMMA; TAMOTSU FURUMAI

doi:10.7164/antibiotics.37.723

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

PENITRICIN, A NEW CLASS OF ANTIBIOTIC PRODUCED BY PENICILLIUM ACULEATUM

III. STRUCTURAL CONFIRMATION BY CHEMICAL SYNTHESIS AND BIOLOGICAL ACTIVITY

TORU OKUDA, NOBUO SHIMMA, TAMOTSU FURUMAI

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JOURNAL FREE ACCESS

1984 Volume 37 Issue 7 Pages 723-727

DOI https://doi.org/10.7164/antibiotics.37.723

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Abstract

A novel antibiotic, penitricin showing anti-Gram-negative activity, has been isolated from the culture filtrate of Penicillium aculeatum. Chemical and physico-chemical studies determined the structure of penitricin as hydroxymethylcyclopropenone (1), which was confirmed by chemical synthesis from propargyl alcohol. Biological activity of penitricin and several cyclopropenones as well as two metabolites, penitricins B and C was compared.

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