MYCOVERSILIN, A NEW ANTIFUNGAL ANTIBIOTIC

I. FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES

Abstract

A new antifungal antibiotic, mycoversilin, was isolated from the culture filtrate of Aspergilus versicolor (N₅)₁₇ by repeated column chromatography and recrystallized from ethyl acetate as homogeneous fine needles. Maximum production took place in a medium containing 4 glucose and 1% peptone at pH 3.5, temperature 28°C after 8-9 days of incubation under stationary condition. Mycoversilin is a narrow spectrum antibiotic with activity against filamentous fungi, particularly Trichophyton rubrum (MIC 15 μg/ml).