BIPHENOMYCINS A AND B, NOVEL PEPTIDE ANTIBIOTICS I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

MASAMI EZAKI; MORITA IWAMI; MICHIO YAMASHITA; SEIJI HASHIMOTO; TADAAKI KOMORI; KAZUYOSHI UMEHARA; YASUHIRO MINE; MASANOBU KOHSAKA; HATSUO AOKI; HIROSHI IMANAKA

doi:10.7164/antibiotics.38.1453

BIPHENOMYCINS A AND B, NOVEL PEPTIDE ANTIBIOTICS

I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

MASAMI EZAKI, MORITA IWAMI, MICHIO YAMASHITA, SEIJI HASHIMOTO, TADAAKI KOMORI, KAZUYOSHI UMEHARA, YASUHIRO MINE, MASANOBU KOHSAKA, HATSUO AOKI, HIROSHI IMANAKA

Author information

MASAMI EZAKI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MORITA IWAMI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MICHIO YAMASHITA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
SEIJI HASHIMOTO
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
TADAAKI KOMORI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
KAZUYOSHI UMEHARA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
YASUHIRO MINE
Central Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
MASANOBU KOHSAKA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
HATSUO AOKI
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
HIROSHI IMANAKA
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.

JOURNAL FREE ACCESS

1985 Volume 38 Issue 11 Pages 1453-1461

DOI https://doi.org/10.7164/antibiotics.38.1453

Details

Abstract

Biphenomycin A, C₂₃H₂₈N₄O₈, and biphenomycin B, C₂₃H₂₈N₄O₇, were isolated from the cultured broth of Streptomyces griseorubiginosus No. 43708. The antibiotics are active in vitro and in vivo against bacteria, and are especially potent against Gram-positive bacteria. The acute toxicity of biphenomycin A is very low in mice.

Corresponding author

Register with J-STAGE for free!