PRODUCTION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES OF ANGIOLAM A, A NEW ANTIBIOTIC FROM ANGIOCOCCUS DISCIFORMIS (MYXOBACTERALES)

Abstract

Angiolam A, a new lactone-lactam antibiotic, was isolated from the culture broth of the myxobacterium Angiococcus disciformis strain An d30. It was active against a few Gram-positive bacteria and mutant strains of Escherichia coli with increased permeability. It appears to interfere with protein synthesis.