The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
A NEW 5'-NUCLEOTIDASE INHIBITOR, NUCLEOTICIDIN
I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
HIROSHI OGAWARAKEIJIRO UCHINOTETSU AKIYAMASHUN-ICHI WATANABE
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1985 Volume 38 Issue 2 Pages 153-156

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Abstract

A new 5'-nucleotidase inhibitor named nucleoticidin was produced by Pseudomonas sp. YM-3229G. It was isolated from a fermentation broth by trichloroacetic acid extraction, ethanol precipitation and Dowex 1 and DEAE-52 column chromatography. It inhibited 5'-nucleotidase activity of snake venom and rat liver membrane. It also showed antitumor activity against solid type Sarcoma 180.

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© Japan Antibiotics Research Association
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