MICROBIAL PHOSPHORYLATION OF COMPACTIN (ML-236B) AND RELATED COMPOUNDS

AKIRA ENDO; HARUYUKI YAMASHITA; HIDEO NAOKI; TAKASHI IWASHITA; YASUMASA MIZUKAWA

doi:10.7164/antibiotics.38.328

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

MICROBIAL PHOSPHORYLATION OF COMPACTIN (ML-236B) AND RELATED COMPOUNDS

AKIRA ENDO, HARUYUKI YAMASHITA, HIDEO NAOKI, TAKASHI IWASHITA, YASUMASA MIZUKAWA

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JOURNAL FREE ACCESS

1985 Volume 38 Issue 3 Pages 328-332

DOI https://doi.org/10.7164/antibiotics.38.328

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Abstract

Several fungal strains were found to convert compactin (ML-236B) to 5'-phosphocompactic acid. The product was isolated by solvent extraction and column chromatography, and identified by IR, UV, ¹H NMR, ¹³C NMR and ³¹P NMR spectroscopy. Related structures (monacolin K, L and X) were also transformed to their corresponding phosphorylated analogues. The products were re-converted back to respective parental compounds by treatment with alkaline phosphatase of calf intestine.

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