The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
STUDIES ON A NOVEL CYTOCIDAL ANTIBIOTIC, TRIENOMYCIN A
TAXONOMY, FERMENTATION, ISOLATION, AND PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERISTICS
IWAO UMEZAWASHINJI FUNAYAMAKENJI OKADAKAZUYO IWASAKIJUNKO SATOHKAZUAKI MASUDAKANKI KOMIYAMA
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1985 Volume 38 Issue 6 Pages 699-705

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Abstract

A new antibiotic, trienomycin A, has been isolated from the culture broth of Streptomyces sp. No. 83-16. The physico-chemical characteristics of the antibiotic suggested that it belongs to the group of ansamycin antibiotics with a triene moiety in the molecule. The molecular formula of trienomycin A is C36H50N3O7( MW 622). The antibiotic possesses potent cytocidal activity against HeLa S3 and PLC hepatoma cells at concentrations of 0.1 and 0.01 μg/ml (IC50 value) respectively. However, trienomycin A showed no antimicrobial activity against the bacteria, fungi and yeasts examined with the exception of weak activity versus Piricularia oryzae at a concentration of 1, 000 μg/ml.

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© Japan Antibiotics Research Association
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