The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
TWO NEW INHIBITORS OF PHOSPHOLIPASE A2 PRODUCED BY PENICILLIUM CHERMESINUM
TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES
PUSHPA D. SINGHJANICE H. JOHNSONCAROL A. AKLONISKAREN BUSHSUSAN M. FISHERJOSEPH O'SULLIVAN
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1985 Volume 38 Issue 6 Pages 706-712

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Abstract

Plastatin and the known fungal metabolite, luteosporin, have been isolated from fermentations of Penicillium chermesinum as inhibitors of porcine pancreatic phospholipase A2 (PLA2). Structure 1 for plastatin was deduced from its spectroscopic properties. Plastatin and luteosporin inhibited pancreatic PLA2 competitively with Ki values of 0.89 μM and 12.8 μM, respectively. PLA2 preparations from Naja naja and Crotalus adamanteus were not significantly inhibited by plastatin and luteosporin.

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© Japan Antibiotics Research Association
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